上海达吉特药业科技有限公司（达吉特）核心团队汇聚了药物化学、药理学、系统生物学等多学科专业人才，公司名称达吉特取英文Target的英译，表达了公司在药物和靶点相关临床前研发领域的专业定位和持续深耕的价值观。达吉特围绕“从药到靶”与“从靶到药”两大研究方向，构建了涵盖中药/复方成分鉴定、活性药物分子筛选、小分子修饰改造、药物靶点发现、SPR分子互作验证及小分子与靶点结合位点确认等一体化技术服务体系。依托完善的技术平台和丰富的项目经验，达吉特持续为创新药研发、天然产物研究及中药现代化提供专业技术支撑。

自2021年成立以来，达吉特已累计为中国大陆和港澳众多重点高校、科研院所、医院及创新药企业提供了高水平的技术服务，为合作者的研究工作持续赋能。截止目前，达吉特已经有上百个交付的项目数据先后在各类国际知名刊物上发表，这些高水平论文正在为新时代中国药物研发事业的发展提供新的思路和新方向。现列举部分达吉特客户已经发表的文章如下： 

小分子修饰与改造

1. Xu Q, Li G, Zhang H, et al. The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases. Nat Commun. Published online March 6, 2026. doi:10.1038/s41467-026-70302-9. (上海交通大学医学院) IF=15.7

2. Han X, Yang YB, Lu QW, et al. Astragalus-derived nano-agonist potentiates chemotherapy by reducing tumor-suppressive macrophages. Acta Pharm Sin B. 2026, ISSN 2211-3835. doi.org/10.1016/j.apsb.2026.03.051. (南京中医药大学) IF=14.6

3. Chen L, Li H, Zhu Q, et al. Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury. J Adv Res. Published online February 1, 2026. doi:10.1016/j.jare.2026.01.075. (扬州大学附属医院) IF=13

4. Shao M, Zhang X, Sun J, et al. Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation. Exploration. 2766-8509. (浙江中医药大学) IF=22.5

5. Chen L, Wu B, Mo L, et al. High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models. Nat Commun. 2025;16(1):2878. Published 2025 Mar 24. doi:10.1038/s41467-025-58188-5. (华中科技大学同济医学院) IF=15.7

6. Ding C, Wang ZP, Shi K, et al. Taxifolin attenuates liver fibrosis by regulating the phosphorylation of NDRG1 at Thr328 via hepatocyte-stellate cell cross talk. Acta Pharm Sin B. 2025, ISSN 2211-3835. doi.org/10.1016/j.apsb.2025.02.017. (浙江中医药大学) IF=14.6

7. Xuan C, Chen D, Zhang S, et al. Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization. Adv Sci (Weinh). Published online April 4, 2025. doi:10.1002/advs.202414587. (中国人民解放军总医院) IF=14.1

8. Yang L, Pi P, Zhang M, et al. Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells. J Adv Res. Published online September 1, 2025. doi:10.1016/j.jare.2025.08.066. (上海健康医学院) IF=13

9. He XM, Zou LF, Yu JT, et al. Discovery of a Novel Non-Nucleoside Inhibitor of RNA-Dependent RNA Polymerase Against Dengue Virus. MedComm (2020). 2025;6(12):e70514. Published 2025 Nov 29. doi:10.1002/mco2.70514. (南方医科大学) IF=10.7

10. Chen L, Liu DH, Li YX, et al. Akebia Saponin D Targeting Ubiquitin Carboxyl-Terminal Hydrolase 4 Promotes Peroxisome Proliferator-Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity. MedComm (2020). 2025;6(11):e70420. Published 2025 Oct 15. doi:10.1002/mco2.70420. (中日友好医院) IF=10.7

11. Su T, Shi Z, Tan J, et al. Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence. Pharmacol Res. 2025;218:107855. doi:10.1016/j.phrs.2025.107855. (广州中医药大学) IF=10.5

12. Cheng Y, Wang G, Yang X, et al. Artesunate alleviates Parkinson's disease by targeting astrocyte MT2A to attenuate dopamine neuronal cuproptosis. Pharmacol Res. Published online August 1, 2025. doi:10.1016/j.phrs.2025.107895. (遵义医科大学) IF=10.5

13. Xia C, Zuo G, Wang M, et al. Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy. Mol Psychiatry. Published online March 25, 2025. doi:10.1038/s41380-025-02959-5. (中日友好医院) IF=9.6

14. Zhao B, Wu K, Sun D, et al. Elevated isatin ameliorates heart injury in patients with myocardial infarction after rehabilitation treatment-based metabolomics screening. Phytomedicine. 2025;148:157260. doi:10.1016/j.phymed.2025.157260. (广州医科大学附属惠州医院) IF=8.3

15. Liao WT, Hu RX, Ji Y, et al. Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease. Phytomedicine. 2025;0944-7113. doi:10.1016/j.phymed.2025.156660. (重庆医科大学第一附属医院) IF=8.3

16. Hu Q, Chen J, Zhang Y, et al. Natural molecule paeoniflorin acts as a gastric mucosal repair agent by targeting PTEN. Phytomedicine. 2025;148:157443. doi:10.1016/j.phymed.2025.157443. (成都中医药大学) IF=8.3

17. Huimin C, Shufen P, Zhaoyu C, et al. Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase. Food Res Int. 2025;221(Pt 3):117392. doi:10.1016/j.foodres.2025.117392. (华中科技大学同济医学院) IF=8

18. Zhang W, Wang Z, Sun R, et al. Exploration of the Combined Mechanism of Direct and Indirect Effects of Paeoniflorin in the Treatment of Cholestasis. Inflammation. 2025;48(5):3006-3021. doi:10.1007/s10753-025-02245-0. (成都中医药大学) IF=5

19. Cui J, Chen Y, Yang Q, et al. Protosappanin A Protects DOX-Induced Myocardial Injury and Cardiac Dysfunction by Targeting ACSL4/FTH1 Axis-Dependent Ferroptosis. Adv Sci (Weinh). 2024;11(34):e2310227. doi:10.1002/advs.202310227. (哈尔滨医科大学附属第二医院) IF=14.1

20. Kang Z, Wang P, Wang B, et al. Echinatin suppresses cutaneous squamous cell carcinoma by targeting GSTM3-mediated ferroptosis. Phytomedicine. 2024;131:155752. doi:10.1016/j.phymed.2024.155752. (上海市皮肤病医院) IF=8.3

21. Hu Q, Chen Y, Zhang W, et al. Dehydroevodiamine targeting IKKβ to alleviate acute gastric injury via inhibiting the p65/NLRP3 axis. Phytomedicine. 2024;134:155963. doi:10.1016/j.phymed.2024.155963. (中国人民解放军总医院) IF=8.3

22. Ma X, Zhang W, Chen Y, et al. Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway. Phytomedicine. 2024;134:156021. doi:10.1016/j.phymed.2024.156021. (成都中医药大学) IF=8.3

23. Li X, Wang G, Li N, et al. Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2. Immunology. 2024;173(1):141-151. doi:10.1111/imm.13818. (重庆医科大学附属第一医院) IF=5

24. Zhang X, Yang Q, Zhang R, et al. Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis. Biofactors. 2024;50(1):74-88. doi:10.1002/biof.1991. (天津中医药大学) IF=5

25. Hu Q, Xie J, Jiang T, et al. Paeoniflorin alleviates DSS-induced ulcerative colitis by suppressing inflammation, oxidative stress, and apoptosis via regulating serum metabolites and inhibiting CDC42/JNK signaling pathway. Int Immunopharmacol. 2024;142(Pt A):113039. doi:10.1016/j.intimp.2024.113039. (成都中医药大学) IF=4.8

26. Luo F, Li H, Ma W, et al. The BCL-2 inhibitor APG-2575 resets tumor-associated macrophages toward the M1 phenotype, promoting a favorable response to anti-PD-1 therapy via NLRP3 activation. Cell Mol Immunol. 2024;21(1):60-79. doi:10.1038/s41423-023-01112-y. (中山大学肿瘤医院) IF=21.8

27. Zeng M, Zhang X, Lv N, et al. Sodium Danshensu stabilizes atherosclerotic vulnerable plaques by targeting IKKβ mediated inflammation in macrophages. Biomed Pharmacother. 2023;165:115153. doi:10.1016/j.biopha.2023.115153. (天津中医药大学) IF=6.9

28. Wang G, Li X, Li N, et al. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biol. 2022;52:102297. doi:10.1016/j.redox.2022.102297. (重庆医科大学附属第一医院) IF=10.7

29. Gao Q, Deng H, Yang Z, et al. Sodium danshensu attenuates cerebral ischemia-reperfusion injury by targeting AKT1. Front Pharmacol. 2022;13:946668. Published 2022 Sep 15. doi:10.3389/fphar.2022.946668. (天津中医药大学) IF=4.4

靶点筛选

1. Xu Q, Li G, Zhang H, et al. The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases. Nat Commun. Published online March 6, 2026. doi:10.1038/s41467-026-70302-9. (上海交通大学医学院) IF=15.7

2. Han X, Yang YB, Lu QW, et al. Astragalus-derived nano-agonist potentiates chemotherapy by reducing tumor-suppressive macrophages. Acta Pharm Sin B. 2026, ISSN 2211-3835. doi.org/10.1016/j.apsb.2026.03.051. (南京中医药大学) IF=14.6

3. Zhang W, Song Y, Li C, et al. Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota-Dependent Manner. Adv Sci (Weinh). Published online May 27, 2026. doi:10.1002/advs.202517222. (郑州大学第一附属医院) IF=14.1

4. Liang Y, Zhang YL, Cheng TY, et al. Senkyunolide H potentiates bone marrow-derived mesenchymal stem cells therapy for liver cirrhosis by targeting MAEA to enhance ERK-driven HGF secretion. Pharmacol Res. 2026;226:108160. doi:10.1016/j.phrs.2026.108160. (上海中医药大学) IF=10.5

5. Zhang S, Tang L, Pu Y, et al. Patchouli alcohol triggers autophagic cell death in non-small cell lung cancer cells through targeting GNAI1 to dissociate the GNAI1/ARRB1 complex. Int J Biol Sci. 2026;22(8):4004-4024. Published 2026 Mar 30. doi:10.7150/ijbs.125690. (中国上海市宝山区吴淞中心医院) IF=10

6. Xue HY, Gu XN, Huang Z, et al. Chlorogenic acid promotes liver regeneration after partial hepatectomy through activating Nrf2 via directly targeting Keap1. Acta Pharmacol Sin. Published online March 20, 2026. doi:10.1038/s41401-026-01770-4. (上海中医药大学) IF=8.4

7. Lan T, Wang W, Zeng XX, Mao WL, Lu T, Wang SW. Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling. Phytomedicine. 2026;156:158244. doi:10.1016/j.phymed.2026.158244. (衢州人民医院) IF=8.3

8. Liang HX, Yuan ZY, Liu RM, et al. Ginkgetin alleviates sepsis-induced acute lung injury by promoting autophagy via inhibiting ubiquitination of Laptm5 in macrophages. Phytomedicine. 2026;153:157894. doi.org/10.1016/j.phymed.2026.157894. (南方医科大学深圳医院) IF=8.3

9. Xie LJ, Wei Q, Ni HF, et al. Asiaticoside attenuates renal fibrosis by targeting STAT3 to restore Th17/Treg homeostasis. Phytomedicine. Published online March 11, 2026. doi:10.1016/j.phymed.2026.158049. (东南大学附属中大医院) IF=8.3

10. Chen L, Zhou X, You Y, et al. Hederagenin Attenuates Cardiac Remodeling by Targeting Phosphodiesterase 9A. Phytother Res. 2026;40(5):2710-2729. doi:10.1002/ptr.70288. (南方医科大学) IF=6.3

11. Gong G, Tang X, Yuan G, Yang X, Wang G, Zhang F. Proteome Microarray-Guided Global View: Multiple Pharmacological Targets of Icariin. Drug Des Devel Ther. 2026;20:581728. Published 2026 Feb 3. doi:10.2147/DDDT.S581728. (重庆医科大学附属第一医院) IF=5.1

12. Zhang Y, Li N, Chu S, Fu H, Yang X, Xia H, Xiao Y, Xiao Z, Liu J, Dong Y and Liu T (2026) Jaranol: a compound with therapeutic activity against pathological cardiac remodelling via multi-target inhibition of the Snai3/TLR2 and NF-κB signaling pathways. Front. Pharmacol. 16:1723889. doi: 10.3389/fphar.2025.1723889. (内蒙古医科大学) IF=4.8

13. Yuan Y, Lyu B, Chu Z, Wu M, Zhang Y. DTX3L promotes renal cell carcinoma progression via ubiquitination and degradation of LATS2. Cell Signal. 2026;138:112216. doi:10.1016/j.cellsig.2025.112216. (深圳市人民医院) IF=3.7

14. Chen YJ, Shi RC, Xiang YC, et al. Malate initiates a proton-sensing pathway essential for pH regulation of inflammation. Signal Transduct Target Ther. 2024;9(1):367. Published 2024 Dec 30. doi:10.1038/s41392-024-02076-9. (陆军军医大学附属第一医院) IF=40.8

15. Hu M, Xu Y, Wang Y, et al. Gut microbial-derived N-acetylmuramic acid alleviates colorectal cancer via the AKT1 pathway. Gut. Published online February 27, 2025. doi:10.1136/gutjnl-2024-332891. (南方医科大学珠江医院) IF=23.1

16. Shao M, Zhang X, Sun J, et al. Saikosaponin b1 Attenuates Liver Fibrosis by Blocking STAT3/Gli1 Interaction and Inducing Gli1 Degradation. Exploration. 2766-8509. (浙江中医药大学) IF=22.5

17. Chen L, Wu B, Mo L, et al. High-content screening identifies ganoderic acid A as a senotherapeutic to prevent cellular senescence and extend healthspan in preclinical models. Nat Commun. 2025;16(1):2878. Published 2025 Mar 24. doi:10.1038/s41467-025-58188-5. (华中科技大学同济医学院) IF=15.7

18. Xu X, Yan Y, Zheng M, et al. Emodin Alleviates Sepsis-Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL-10. Adv Sci (Weinh). 2025 Aug 8:e17129. (首都医科大学附属北京中医医院) IF=14.1

19. Xuan C, Chen D, Zhang S, et al. Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization. Adv Sci (Weinh). Published online April 4, 2025. doi:10.1002/advs.202414587. (中国人民解放军总医院) IF=14.1

20. Yang X, Lin G, Chen Y, et al. Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase. ACS Cent Sci. 2024;10(9):1789-1802. Published 2024 Aug 28. doi:10.1021/acscentsci.4c00798. (广州医科大学) IF=12.7

21. Han RY, Tan RZ, Xu LH, et al. Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD. Redox Biol. Published online July 8, 2025. doi:10.1016/j.redox.2025.103762. (西南医科大学附属中医医院) IF=11.9

22. Chen L, Liu DH, Li YX, et al. Akebia Saponin D Targeting Ubiquitin Carboxyl-Terminal Hydrolase 4 Promotes Peroxisome Proliferator-Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity. MedComm (2020). 2025;6(11):e70420. Published 2025 Oct 15. doi:10.1002/mco2.70420. (中日友好医院) IF=10.7

23. Cheng Y, Wang G, Yang X, et al. Artesunate alleviates Parkinson's disease by targeting astrocyte MT2A to attenuate dopamine neuronal cuproptosis. Pharmacol Res. Published online August 1, 2025. doi:10.1016/j.phrs.2025.107895. (遵义医科大学) IF=10.5

24. Su T, Shi Z, Tan J, et al. Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence. Pharmacol Res. 2025;218:107855. doi:10.1016/j.phrs.2025.107855. (广州中医药大学) IF=10.5

25. Zhao R, Lu Y, Xu Q, et al. Gut blautia coccoides-derived 5Z-dodecenoic acid attenuates chronic psychological stress-induced gastric cancer progression. Int J Surg. Published online November 20, 2025. doi:10.1097/JS9.0000000000004080. (中国人民解放军总医院第一医学中心) IF=10.3

26. Xia C, Zuo G, Wang M, et al. Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy. Mol Psychiatry. Published online March 25, 2025. doi:10.1038/s41380-025-02959-5. (中日友好医院) IF=9.6

27. Hu Q, Chen J, Zhang Y, et al. Natural molecule paeoniflorin acts as a gastric mucosal repair agent by targeting PTEN. Phytomedicine. 2025;148:157443. doi:10.1016/j.phymed.2025.157443. (成都中医药大学) IF=8.3

28. Lin GS, Zheng RQ, Xu ZW, et al. Proteomic screening identifies brusatol targets TGFβRII to suppresses non-small cell lung cancer metastasis. Phytomedicine. 2025;139:156468. doi:10.1016/j.phymed.2025.156468. (广州中医药大学) IF=8.3

29. Zhao B, Wu K, Sun D, et al. Elevated isatin ameliorates heart injury in patients with myocardial infarction after rehabilitation treatment-based metabolomics screening. Phytomedicine. 2025;148:157260. doi:10.1016/j.phymed.2025.157260. (广州医科大学附属惠州医院) IF=8.3

30. Liao WT, Hu RX, Ji Y, et al. Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease. Phytomedicine. 2025;0944-7113. doi:10.1016/j.phymed.2025.156660. (重庆医科大学第一附属医院) IF=8.3

31. Bai H, Zhang Y, Zhang X, et al. Zyxin-a novel detrimental target, is inhibited by Saikosaponin A during allergic asthma. Phytomedicine. 2025;138:156434. doi:10.1016/j.phymed.2025.156434. (西安交通大学) IF=8.3

32. Ai S, Tao J, Wang Y, et al. Paeonol ameliorates diabetic nephropathy by promoting TFEB-mediated lysosome biogenesis and lipophagy. Phytomedicine. 2025 Jul 25;143:156901. doi: 10.1016/j.phymed.2025.156901. Epub 2025 May 24. PMID: 40466504. (北京中医药大学东直门医院) IF=8.3

33. Li X, Zhao S, Xie J, et al. Targeting the NF-κB p65-MMP28 axis: Wogonoside as a novel therapeutic agent for attenuating podocyte injury in diabetic nephropathy. Phytomedicine. 2025;138:156406. doi:10.1016/j.phymed.2025.156406. (上海交通大学医学院附属新华医院) IF=8.3

34. Wang SW, Li P, Liu SY, et al. Astragaloside IV inhibits retinal pigment epithelial cell senescence and reduces IL-1β mRNA stability by targeting FTO-mediated m6A methylation. Phytomedicine. 2025;138:156408. doi:10.1016/j.phymed.2025.156408. (浙江中医药大学) IF=8.3

35. Huimin C, Shufen P, Zhaoyu C, et al. Quercetin alleviates ethanol-induced hepatocyte senescence by interacting with glycinamide ribonucleotide transformylase. Food Res Int. 2025;221(Pt 3):117392. doi:10.1016/j.foodres.2025.117392. (华中科技大学同济医学院) IF=8

36. Jiang B, Zhang H, Xu Q, Jiang Z, He R, Fu Q, Sun Y. Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. Aging Cell. 2025 Jun 19:e70138. doi: 10.1111/acel.70138. (上海营养与健康研究所-抗衰老) IF=7.1

37. Luo Z, Fan H, Zhang T, et al. A novel benzofuran derivative of β-elemene (ZT-22) inhibits hepatocellular carcinoma cell growth via directly targeting HSPA6. Chem Biol Interact. 2025;415:111514. doi:10.1016/j.cbi.2025.111514. (中国中医科学院中药研究所) IF=5.4

38. Zhang W, Wang Z, Sun R, et al. Exploration of the Combined Mechanism of Direct and Indirect Effects of Paeoniflorin in the Treatment of Cholestasis. Inflammation. 2025;48(5):3006-3021. doi:10.1007/s10753-025-02245-0. (成都中医药大学) IF=5

39. Xie Z, Cao N, Li M, et al. Exploration of the potential neurotransmitter or neuromodulator-like properties of harmine: evidence from synthesis to synaptic modulation. Front Pharmacol. 2025;16:1588105. Published 2025 Jul 7. doi:10.3389/fphar.2025.1588105. (上海中医药大学) IF=4.8

40. Hou Y, Yang Y, Zhao Z, et al. Capsazepine Inhibits Astrocyte Activation and Attenuates Neuroinflammation by Targeting Syntaxin 7. FASEB J. 2025;39(10):e70657. doi:10.1096/fj.202500523R. (上海中医药大学) IF=4.2

41. L Qiu, C Ming, Chen Guang, et al. Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway. J. Funct. Foods. ISSN 1756-4646. 10.1016/j.jff.2025.106684. (暨南大学) IF=4

42. Zhou J, Song Q, Li H, et al. Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis. Mol Cancer. 2024;23(1):168. Published 2024 Aug 20. doi:10.1186/s12943-024-02086-9. (上海中医药大学附属曙光医院) IF=27.7

43. Li D, Wei R, Zhang X, et al. Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice. Acta Pharm Sin B. 2024;14(7):3068-3085. doi:10.1016/j.apsb.2024.03.025. (南方医科大学) IF=14.6

44. Cui J, Chen Y, Yang Q, et al. Protosappanin A Protects DOX-Induced Myocardial Injury and Cardiac Dysfunction by Targeting ACSL4/FTH1 Axis-Dependent Ferroptosis. Adv Sci (Weinh). 2024;11(34):e2310227. doi:10.1002/advs.202310227. (哈尔滨医科大学附属第二医院) IF=14.1

45. Chen S, Ma X, Liu Y, et al. Creatine Promotes Endometriosis by Inducing Ferroptosis Resistance via Suppression of PrP. Adv Sci (Weinh). 2024;11(38):e2403517. doi:10.1002/advs.202403517. (复旦大学附属妇产科医院) IF=14.1

46. Zheng Y, Zhao L, Xiong Z, et al. Ursolic acid targets secreted phosphoprotein 1 to regulate Th17 cells against metabolic dysfunction-associated steatotic liver disease. Clin Mol Hepatol. 2024;30(3):449-467. doi:10.3350/cmh.2024.0047. (上海中医药大学联合广州中医药大学) IF=14

47. Deng Y, Zeng L, Liu H, et al. Silibinin attenuates ferroptosis in acute kidney injury by targeting FTH1. Redox Biol. 2024;77:103360. doi:10.1016/j.redox.2024.103360. (南方医科大学) IF=10.7

48. Liu F, He H, Yang W, et al. Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1. Cell Commun Signal. 2024;22(1):383. Published 2024 Jul 29. doi:10.1186/s12964-024-01757-w. (北京药理毒理研究所) IF=8.9

49. Liu F, He H, Yang W, et al. Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1. Cell Commun Signal. 2024;22(1):383. Published 2024 Jul 29. doi:10.1186/s12964-024-01757-w. (北京市毒理药物研究所) IF=8.9

50. Kang Z, Wang P, Wang B, et al. Echinatin suppresses cutaneous squamous cell carcinoma by targeting GSTM3-mediated ferroptosis. Phytomedicine. 2024;131:155752. doi:10.1016/j.phymed.2024.155752. (上海市皮肤病医院) IF=8.3

51. Ma X, Zhang W, Chen Y, et al. Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway. Phytomedicine. 2024;134:156021. doi:10.1016/j.phymed.2024.156021. (成都中医药大学) IF=8.3

52. Hu Q, Chen Y, Zhang W, et al. Dehydroevodiamine targeting IKKβ to alleviate acute gastric injury via inhibiting the p65/NLRP3 axis. Phytomedicine. 2024;134:155963. doi:10.1016/j.phymed.2024.155963. (中国人民解放军总医院) IF=8.3

53. Jia W, Liang S, Jin M, et al. Oleanolic acid inhibits hypoxic tumor-derived exosomes-induced premetastatic niche formation in hepatocellular carcinoma by targeting ERK1/2-NFκB signaling. Phytomedicine. 2024;126:155208. doi:10.1016/j.phymed.2023.155208. (海军军医大学第一附属医院) IF=8.3

54. Lu H, Fan L, Zhang W, et al. The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression. Cell Rep. 2024;43(1):113587. doi:10.1016/j.celrep.2023.113587. (西安第四军医大学) IF=7.5

55. Shan L, Chen Y, An G, et al. Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway. Chin Med. 2024;19(1):113. Published 2024 Aug 24. doi:10.1186/s13020-024-00984-0. (北京中医药大学) IF=5.3

56. Li X, Wang G, Li N, et al. Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2. Immunology. 2024;173(1):141-151. doi:10.1111/imm.13818. (重庆医科大学附属第一医院) IF=5

57. Zhang X, Yang Q, Zhang R, et al. Sodium Danshensu ameliorates cerebral ischemia/reperfusion injury by inhibiting CLIC4/NLRP3 inflammasome-mediated endothelial cell pyroptosis. Biofactors. 2024;50(1):74-88. doi:10.1002/biof.1991. (天津中医药大学) IF=5

58. Mei C, Zhang X, Zhi Y, et al. Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR-STAT3 Signaling Pathway in Canine Mammary Tumors. Int J Mol Sci. 2024;25(1):670. Published 2024 Jan 4. doi:10.3390/ijms25010670. (北京市农林科学院) IF=4.9

59. Hu Q, Xie J, Jiang T, et al. Paeoniflorin alleviates DSS-induced ulcerative colitis by suppressing inflammation, oxidative stress, and apoptosis via regulating serum metabolites and inhibiting CDC42/JNK signaling pathway. Int Immunopharmacol. 2024;142(Pt A):113039. doi:10.1016/j.intimp.2024.113039. (成都中医药大学) IF=4.8

60. Huang H, Liang X, Wu W, et al. FOXP3-regulated lncRNA NONHSAT136151 promotes colorectal cancer progression by disrupting QKI interaction with target mRNAs. J Cell Mol Med. 2024;28(2):e18068. doi:10.1111/jcmm.18068. (苏州大学) IF=4.3

61. Ma X, Hu Q, Jiang T, et al. Dehydroevodiamine Alleviates Ulcerative Colitis by Inhibiting the PI3K/AKT/NF-κB Signaling Pathway via Targeting AKT1 and Regulating Gut Microbes and Serum Metabolism. Molecules. 2024;29(17):4031. Published 2024 Aug 26. doi:10.3390/molecules29174031. (成都中医药大学) IF=4.2

62. Feng M, Zhang L, Yin A, Zhang H, Wu X, Qian L. Peptide PDRPS6 attenuates myocardial ischemia injury by improving mitochondrial function. Eur J Pharmacol. 2024;974:176570. doi:10.1016/j.ejphar.2024.176570. (上海交通大学医学院附属同仁医院虹桥国际医学研究所) IF=4.2

63. Liu J, Ren Z, Sun Y, et al. Investigation of the Relationship between Aptamers' Targeting Functions and Human Plasma Proteins. ACS Nano. 2023;17(23):24329-24342. doi:10.1021/acsnano.3c10238. (上海交通大学医学院仁济医院) IF=15.8

64. Zhong J, He X, Gao X, et al. Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling. Nat Commun. 2023;14(1):5451. Published 2023 Sep 6. doi:10.1038/s41467-023-41061-8. (上海中医药大学) IF=15.7

65. Deng Y, Zeng X, Lv Y, et al. Cdyl2-60aa encoded by CircCDYL2 accelerates cardiomyocyte death by blocking APAF1 ubiquitination in rats. Exp Mol Med. 2023;55(4):860-869. doi:10.1038/s12276-023-00983-5. (南京医科大学附属南京第一医院) IF=9.5

66. Li Z, Fan Q, Chen M, et al. The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway. J Pharm Anal. 2023;13(1):39-54. doi:10.1016/j.jpha.2022.11.005. (北京中医药大学) IF=8.9

67. Sun Y, Yu D, Geng X, et al. Artificial Base-Directed In Vivo Assembly of an Albumin-siRNA Complex for Tumor-Targeting Delivery. ACS Appl Mater Interfaces. Published online February 7, 2023. doi:10.1021/acsami.2c19075. (上海大学医学院) IF=8.3

68. Zeng M, Zhang X, Lv N, et al. Sodium Danshensu stabilizes atherosclerotic vulnerable plaques by targeting IKKβ mediated inflammation in macrophages. Biomed Pharmacother. 2023;165:115153. doi:10.1016/j.biopha.2023.115153. (天津中医药大学) IF=6.9

69. Zhang Y, Bao S, Wang D, et al. Downregulation of KLF10 contributes to the regeneration of survived renal tubular cells in cisplatin-induced acute kidney injury via ZBTB7A-KLF10-PTEN axis. Cell Death Discov. 2023;9(1):82. Published 2023 Mar 6. doi:10.1038/s41420-023-01381-6. (复旦大学附属中山医院) IF=6.1

70. Zhou WJ, Yang HL, Mei J, et al. Fructose-1,6-bisphosphate prevents pregnancy loss by inducing decidual COX-2+ macrophage differentiation. Sci Adv. 2022;8(8):eabj2488. doi:10.1126/sciadv.abj2488. (复旦大学附属妇产科医院) IF=12.5

71. Zhao T, Zeng J, Xu Y, et al. Chitinase-3 like-protein-1 promotes glioma progression via the NF-κB signaling pathway and tumor microenvironment reprogramming. Theranostics. 2022;12(16):6989-7008. Published 2022 Oct 3. doi:10.7150/thno.75069. (广州医科大学) IF=12.4

72. Wang G, Li X, Li N, et al. Icariin alleviates uveitis by targeting peroxiredoxin 3 to modulate retinal microglia M1/M2 phenotypic polarization. Redox Biol. 2022;52:102297. doi:10.1016/j.redox.2022.102297. (重庆医科大学附属第一医院) IF=10.7

73. Zhu Y, Zhou B, Hu X, et al. LncRNA LINC00942 promotes chemoresistance in gastric cancer by suppressing MSI2 degradation to enhance c-Myc mRNA stability. Clin Transl Med. 2022;12(1):e703. doi:10.1002/ctm2.703. (浙江大学) IF=7.9

74. Gao Q, Deng H, Yang Z, et al. Sodium danshensu attenuates cerebral ischemia-reperfusion injury by targeting AKT1. Front Pharmacol. 2022;13:946668. Published 2022 Sep 15. doi:10.3389/fphar.2022.946668. (天津中医药大学) IF=4.4

75. Wu S, Li Z, Li H, Liao K. Dihydroartemisinin Reduces Irradiation-Induced Mitophagy and Radioresistance in Lung Cancer A549 Cells via CIRBP Inhibition. Life (Basel). 2022;12(8):1129. Published 2022 Jul 27. doi:10.3390/life12081129. (重庆医科大学附属第一医院) IF=3.2

76. Gu Y, Chen Y, Wei L, et al. Author Correction: ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation. Nat Commun. 2023;14(1):1875. Published 2023 Apr 4. doi:10.1038/s41467-023-37521-w. (第三军医大学) IF=15.7

77. Zhang P, Tao W, Lu C, et al. Bruceine A induces cell growth inhibition and apoptosis through PFKFB4/GSK3β signaling in pancreatic cancer. Pharmacol Res. 2021;169:105658. doi:10.1016/j.phrs.2021.105658. (南京中医药大学) IF=9.1

78. Xu Y, Liu C, Han X, et al. E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021;41(6):e284-e298. doi:10.1161/ATVBAHA.120.314156. (中国医学科学院医药生物技术研究所) IF=7.4

79. Zheng Y, Huang C, Zhao L, Chen Y, Liu F. Regulation of decorin by ursolic acid protects against non-alcoholic steatohepatitis. Biomed Pharmacother. 2021;143:112166. doi:10.1016/j.biopha.2021.112166. (上海中医药大学联合广州中医药大学) IF=6.9

80. Chen W, Jia W, Wu C, et al. The Neurogenic Compound P7C3 Regulates the Aerobic Glycolysis by Targeting Phosphoglycerate Kinase 1 in Glioma. Front Oncol. 2021;11:644492. Published 2021 Jun 18. doi:10.3389/fonc.2021.644492. (南方医科大学) IF=3.5

81. Wang CL, Li JC, Zhou CX, et al. Long non-coding RNA ARHGAP5-AS1 inhibits migration of breast cancer cell via stabilizing SMAD7 protein. Breast Cancer Res Treat. 2021;189(3):607-619. doi:10.1007/s10549-021-06286-5. (上海交通大学) IF=3

82. Yu B, Qu L, Wu T, et al. A Novel LncRNA, AC091729.7 Promotes Sinonasal Squamous Cell Carcinomas Proliferation and Invasion Through Binding SRSF2. Front Oncol. 2020;9:1575. Published 2020 Jan 24. doi:10.3389/fonc.2019.01575. (哈尔滨医科大学第二附属医院) IF=3.5

83. Chen XJ, Zhang WN, Chen B, et al. Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor. Proc Natl Acad Sci U S A. 2019;116(6):2220-2225. doi:10.1073/pnas.1818539116. (上海交通大学医学院附属瑞金医院) IF=9.4

84. Shen SM, Ji Y, Zhang C, et al. Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. 2018;9(1):2392. Published 2018 Jun 19. doi:10.1038/s41467-018-04760-1. (上海交通大学) IF=15.7

85. Qin M, Wei G, Sun X. Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing. Biochem Biophys Res Commun. 2018;503(2):1027-1034. doi:10.1016/j.bbrc.2018.06.112. (上海交通大学) IF=2.5

SPR表面等离子共振

1. Ding L, Yin C, Guo Y, et al. Direct coupling and protective activation of DRP1 by the DNA-PKcs inhibitor KU-57788 synergizes with ferroptosis in anaplastic thyroid cancer cells. Cell Death Dis. Published online April 28, 2026. doi:10.1038/s41419-026-08595-3. (浙江省人民医院) IF=9.6

2. Hou X, Chen L, Huang Y, et al. Natural AhR ligands: A novel approach to dynamic immune regulation in viral infections. Phytomedicine. Published online May 17, 2026. doi:10.1016/j.phymed.2026.158312. (南京中医药大学) IF=8.3

3. Xie LJ, Wei Q, Ni HF, et al. Asiaticoside attenuates renal fibrosis by targeting STAT3 to restore Th17/Treg homeostasis. Phytomedicine. Published online March 11, 2026. doi:10.1016/j.phymed.2026.158049. (东南大学附属中大医院) IF=8.3

4. Hu M, Xu Y, Wang Y, et al. Gut microbial-derived N-acetylmuramic acid alleviates colorectal cancer via the AKT1 pathway. Gut. Published online February 27, 2025. doi:10.1136/gutjnl-2024-332891. (南方医科大学珠江医院) IF=23.1

5. Xu X, Yan Y, Zheng M, et al. Emodin Alleviates Sepsis-Induced Multiorgan Damage by Inhibiting NETosis through Targeting Neutrophils BCL-10. Adv Sci (Weinh). 2025 Aug 8:e17129. (首都医科大学附属北京中医医院) IF=14.1

6. Xuan C, Chen D, Zhang S, et al. Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization. Adv Sci (Weinh). Published online April 4, 2025. doi:10.1002/advs.202414587. (中国人民解放军总医院) IF=14.1

7. Wang J, Song Y, Tan X, et al. Targeting PIM1 by Bruceine D attenuates skin fibrosis via myofibroblast ferroptosis. Redox Biol. 2025;82:103619. doi:10.1016/j.redox.2025.103619. (第四军医大学西京医院) IF=11.9

8. Tan J, Feng S, Dang W, et al. Acyl-CoA synthetase long-chain family member 4 (ACSL4)-targeting fluorescent probes for precision intraoperative visualization of hepatocellular carcinoma. J Control Release. Published online September 3, 2025. doi:10.1016/j.jconrel.2025.114161. (复旦大学附属中山医院) IF=11.5

9. Su T, Shi Z, Tan J, et al. Casticin activates Rheb GTPase by binding to residue Trp141 and induces tumor senescence. Pharmacol Res. 2025;218:107855. doi:10.1016/j.phrs.2025.107855. (广州中医药大学) IF=10.5

10. Zhao R, Lu Y, Xu Q, et al. Gut blautia coccoides-derived 5Z-dodecenoic acid attenuates chronic psychological stress-induced gastric cancer progression. Int J Surg. Published online November 20, 2025. doi:10.1097/JS9.0000000000004080. (中国人民解放军总医院第一医学中心) IF=10.3

11. Xia C, Zuo G, Wang M, et al. Targeting HINT1 to improve synaptic plasticity: toward loganin as a new antidepressant strategy. Mol Psychiatry. Published online March 25, 2025. doi:10.1038/s41380-025-02959-5. (中日友好医院) IF=9.6

12. Chen X, Zhang C, Ye Y, et al. Notopterol attenuates synovitis via α7nAChR-dependent metabolic reprogramming of macrophage polarisation. Phytomedicine. 2026;150:157684. doi:10.1016/j.phymed.2025.157684. (福建中医药大学) IF=8.3

13. Deng ZH, He LJ, Wei S, et al. Unveiling plumbagin as a novel metabolic modulator to suppress ACC1-mediated de novo lipogenesis in non-small cell lung cancer. Phytomedicine. 2025;148:157438. doi:10.1016/j.phymed.2025.157438. (广西医科大学) IF=8.3

14. Cheng K, Lin J, Wu M, et al. Berberine promotes hair growth by targeting Axin2 and activating Wnt/β-catenin pathway. Phytomedicine. 2025;141:156669. doi:10.1016/j.phymed.2025.156669. (复旦大学附属华山医院) IF=8.3

15. Kong Q, Liu S, He S, et al. Celastrol enhanced CD8+T cell immunity in melanoma by targeting SHP2 and upregulating MHC-I. Phytomedicine. 2025;142:156731. doi:10.1016/j.phymed.2025.156731. (复旦大学附属华山医院) IF=8.3

16. Liao WT, Hu RX, Ji Y, et al. Oleic acid regulates CD4+ T cells differentiation by targeting ODC1-mediated STAT5A phosphorylation in Vogt-Koyanagi-Harada disease. Phytomedicine. 2025;0944-7113. doi:10.1016/j.phymed.2025.156660. (重庆医科大学第一附属医院) IF=8.3

17. Li Z, Gao K, Wang M, et al. Naringin inhibits the osteoblast-osteoclast pyroptosis cascade reaction mediated by accumulated bone marrow adipose tissue in the treatment of postmenopausal osteoporosis. J Orthop Translat. 2025;55:323-338. Published 2025 Oct 1. doi:10.1016/j.jot.2025.09.004. (山东中医药大学) IF=7.8

18. Du X, Ma C, Wang Y, et al. The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma. Respir Res. 2025;26(1):203. Published 2025 May 29. doi:10.1186/s12931-025-03281-y. (大连医科大学附属第二医院) IF=5

19. Peng L, Guo X, Kong X, et al. The mechanism of luteolin suppressing pancreatic cancer (PC) via cyclin B1 (CCNB1)-mediated signalling. Sci Rep. 2025;15(1):42044. Published 2025 Nov 26. doi:10.1038/s41598-025-25973-7. (河南大学第一附属医院) IF=3.9

20. Zhou J, Song Q, Li H, et al. Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis. Mol Cancer. 2024;23(1):168. Published 2024 Aug 20. doi:10.1186/s12943-024-02086-9. (上海中医药大学附属曙光医院) IF=27.7

21. Liu H, Xu L, Yue S, et al. Targeting N4-acetylcytidine suppresses hepatocellular carcinoma progression by repressing eEF2-mediated HMGB2 mRNA translation. Cancer Commun (Lond). 2024;44(9):1018-1041. doi:10.1002/cac2.12595. (华中科技大学同济医学院附属同济医院) IF=24.9

22. Lin W, Wang N, Wu S, et al. NUAK1-Mediated Phosphorylation of NADK Mitigates ROS Accumulation to Promote Osimertinib Resistance in Non-Small Cell Lung Carcinoma. Cancer Res. 2024;84(23):4081-4098. doi:10.1158/0008-5472. (华中科技大学同济医学院附属协和医院) IF=16.6

23. Jia L, Jiang Y, Wu L, et al. Porphyromonas gingivalis aggravates colitis via a gut microbiota-linoleic acid metabolism-Th17/Treg cell balance axis. Nat Commun. 2024;15(1):1617. Published 2024 Feb 22. doi:10.1038/s41467-024-45473-y. (首都医科大学附属北京口腔医院) IF=15.7

24. Li D, Wei R, Zhang X, et al. Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice. Acta Pharm Sin B. 2024;14(7):3068-3085. doi:10.1016/j.apsb.2024.03.025. (南方医科大学) IF=14.6

25. Bai M, Xu S, Jiang M, et al. Meis1 Targets Protein Tyrosine Phosphatase Receptor J in Fibroblast to Retard Chronic Kidney Disease Progression. Adv Sci (Weinh). 2024;11(39):e2309754. doi:10.1002/advs.202309754. (南京医科大学附属儿童医院) IF=14.1

26. Xu L, Liu Q, Liu H, et al. Disrupting CCDC137-mediated LZTS2 and β-TrCP interaction in the nucleus inhibits hepatocellular carcinoma development via β-catenin and AKT. Cell Death Differ. 2025;32(1):134-148. doi:10.1038/s41418-024-01328-z. (华中科技大学) IF=13.7

27. Liu F, He H, Yang W, et al. Novel energy optimizer, meldonium, rapidly restores acute hypobaric hypoxia-induced brain injury by targeting phosphoglycerate kinase 1. Cell Commun Signal. 2024;22(1):383. Published 2024 Jul 29. doi:10.1186/s12964-024-01757-w. (北京药理毒理研究所) IF=8.9

28. Zhou W, Zuo H, Qian Y, Miao W, Chen C. Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of the Nrf2 signaling pathway. Chem Biol Interact. 2024;395:111032. doi:10.1016/j.cbi.2024.111032. (衢州市人民医院) IF=8.3

29. Wang ZQ, Wu ZX, Chen JW, et al. Cyclovirobuxine D inhibits triple-negative breast cancer via YAP/TAZ suppression and activation of the FOXO3a/PINK1-Parkin pathway-induced mitophagy. Phytomedicine. 2025;136:156287. doi:10.1016/j.phymed.2024.156287. (温州医科大学) IF=8.3

30. Lu H, Fan L, Zhang W, et al. The mitochondrial genome-encoded peptide MOTS-c interacts with Bcl-2 to alleviate nonalcoholic steatohepatitis progression. Cell Rep. 2024;43(1):113587. doi:10.1016/j.celrep.2023.113587. (西安第四军医大学) IF=7.5

31. Wang Z, Shao Y, Wu F, et al. Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension. Microbiol Res. 2024;287:127824. doi:10.1016/j.micres.2024.127824. (南方医科大学深圳医院) IF=6.9

32. heng R, Li Y, Wu Y, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024;172:116220. doi:10.1016/j.biopha.2024.116220. (北京协和医学院) IF=6.9

33. Li D, Chang J, Wang Y, et al. Hyperoside mitigates photoreceptor degeneration in part by targeting cGAS and suppressing DNA-induced microglial activation. Acta Neuropathol Commun. 2024;12(1):76. Published 2024 May 16. doi:10.1186/s40478-024-01793-0. (上海中医药大学附属岳阳中西结合医院) IF=5.7

34. Mei C, Zhang X, Zhi Y, et al. Isorhamnetin Regulates Programmed Death Ligand-1 Expression by Suppressing the EGFR-STAT3 Signaling Pathway in Canine Mammary Tumors. Int J Mol Sci. 2024;25(1):670. Published 2024 Jan 4. doi:10.3390/ijms25010670. (北京市农林科学院畜牧兽医研究所) IF=4.9

35. Qin Y, Li W, Liu J, et al. Andrographolide ameliorates sepsis-induced acute lung injury by promoting autophagy in alveolar macrophages via the RAGE/PI3K/AKT/mTOR pathway. Int Immunopharmacol. 2024;139:112719. doi:10.1016/j.intimp.2024.112719. (重庆医科大学附属第一医院) IF=4.7

36. Shan L, Chen Y, An G, et al. Polyphyllin I exerts anti-hepatocellular carcinoma activity by targeting ZBTB16 to activate the PPARγ/RXRα signaling pathway. Chin Med. 2024;19(1):113. Published 2024 Aug 24. doi:10.1186/s13020-024-00984-0. (北京中医药大学) IF=4.7

37. Luo Z, Li Q, He S, et al. Berberine sensitizes immune checkpoint blockade therapy in melanoma by NQO1 inhibition and ROS activation. Int Immunopharmacol. 2024;142(Pt A):113031. doi:10.1016/j.intimp.2024.113031. (复旦大学附属华山医院) IF=4.7

38. Wang X, Sui X, Sun Y, et al. Potential Common Mechanisms of Cytotoxicity Induced by Organophosphorus Pesticides via NLRP3 Inflammasome Activation. Geohealth. 2024;8(4):e2023GH000888. Published 2024 Apr 18. doi:10.1029/2023GH000888. (东北大学) IF=3.8

39. Liu Y, Xia G, Chen Y, et al. Purpurolide C-based microneedle promotes macrophage-mediated diabetic wound healing via inhibiting TLR4-MD2 dimerization and MYD88 phosphorylation. Acta Pharm Sin B. 2023;13(12):5060-5073. doi:10.1016/j.apsb.2023.05.032. (首都医科大学口腔医学院) IF=14.6

40. Li Z, Fan Q, Chen M, et al. The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway. J Pharm Anal. 2023;13(1):39-54. doi:10.1016/j.jpha.2022.11.005. (北京中医药大学) IF=6.1

41. Yang R, Liu L, Jiang D, et al. Identification of Potential TMPRSS2 Inhibitors for COVID-19 Treatment in Chinese Medicine by Computational Approaches and Surface Plasmon Resonance Technology. J Chem Inf Model. 2023;63(10):3005-3017. doi:10.1021/acs.jcim.2c01643. (深圳市中医院) IF=5.6

42. Hu X, Li M, Zhang Y, et al. An innovative immunotherapeutic strategy for rheumatoid arthritis: Selectively suppressing angiogenesis and osteoclast differentiation by fully human antibody targeting thymocyte antigen-1. Exp Cell Res. 2023;424(1):113490. doi:10.1016/j.yexcr.2023.113490. (温州医科大学) IF=3.5

43. Bai T, Wang X, Qin C, et al. Deficiency of mindin reduces renal injury after ischemia reperfusion. Mol Med. 2022;28(1):152. Published 2022 Dec 12. doi:10.1186/s10020-022-00578-2. (华中科技大学同济医学院附属武汉第一医院) IF=6.4

44. He S, Wang S, Liu S, Li Z, Liu X, Wu J. Baicalein Potentiated M1 Macrophage Polarization in Cancer Through Targeting PI3Kγ/ NF-κB Signaling. Front Pharmacol. 2021;12:743837. Published 2021 Aug 25. doi:10.3389/fphar.2021.743837. (复旦大学附属华山医院) IF=4.8

45. Ye S, Luo W, Khan ZA, et al. Celastrol Attenuates Angiotensin II-Induced Cardiac Remodeling by Targeting STAT3 . Circ Res. 2020;126(8):1007-1023. doi:10.1161/CIRCRESAHA.119.315861. (温州医科大学) IF=16.5

46. Chen X, Zhao Y, Luo W, et al. Celastrol induces ROS-mediated apoptosis via directly targeting peroxiredoxin-2 in gastric cancer cells. Theranostics. 2020;10(22):10290-10308. Published 2020 Aug 15. doi:10.7150/thno.46728. (温州医科大学) IF=12.4

中药复方成分鉴定

1. Zou X, Cai A, Cheng Y, et al. An integrated study on the role and underlying mechanism of QingFei Oral solution in pulmonary hypertension. Phytomedicine. 2025;148:157311. doi:10.1016/j.phymed.2025.157311. (浙江省人民医院) IF=8.3

2. Zheng L，Li L, et al.Huangjing Yangji Decoction ameliorates skeletal muscle aging and mitochondrial dysfunction via SIRT1/ATF5-mediated mitochondrial unfolded protein response. Phytomedicine. 2025; ISSN 0944-7113. doi.org/10.1016/j.phymed.2025.157432. (中国中医科学院望京医院) IF=8.3

3. Yang Y, Gan D, Liang B, et al. Quyushengxin formula restores the integrity of intestinal barrier by regulating the gut microbiota to ameliorate DSS-induced ulcerative colitis in mice. J Ethnopharmacol. Published online December 2, 2025. doi:10.1016/j.jep.2025.120992. (上海中医药大学附属曙光医院) IF=5.4

4. Ji L, Wei J, Zhang R, et al. Bushen Formula promotes the decrease of HBsAg levels in patients with CHB by regulating Tfh cells and B-cell subsets. J Ethnopharmacol. 2024;328:118072. doi:10.1016/j.jep.2024.118072. (上海中医药大学附属曙光医院) IF=5.4

5. Shang Z, Gao Y, Xue Y, et al. Shenge Formula attenuates high-fat diet-induced obesity and fatty liver via inhibiting ACOX1. Phytomedicine. 2024;123:155183. doi:10.1016/j.phymed.2023.155183. (上海中医药大学附属曙光医院) IF=8.3

6. Lu Y, Zhao D, Liu M, et al. Gongying-Jiedu-Xiji recipe promotes the healing of venous ulcers by inhibiting ferroptosis via the CoQ-FSP1 axis. Front Pharmacol. 2023;14:1291099. Published 2023 Dec 15. doi:10.3389/fphar.2023.1291099. (山东中医药大学) IF=4.4

7. 7. Zhao Y, Ma C, Qiu Q, et al. Exploring the components and mechanisms of Shen-qi-wang-mo granule in the treatment of retinal vein occlusion by UPLC-Triple TOF MS/MS and network pharmacology. Sci Rep. 2023;13(1):5330. Published 2023 Apr 1. doi:10.1038/s41598-023-32472-0. (上海交通大学) IF=3.8

8. Li S, Liu P, Feng X, et al. Mechanism of Tao Hong Decoction in the treatment of atherosclerosis based on network pharmacology and experimental validation. Front Cardiovasc Med. 2023;10:1111475. Published 2023 Jan 26. doi:10.3389/fcvm.2023.1111475. (上海中医药大学龙华医院) IF=2.8

9. Chen Q, Zhang YL, Zhang ZW, et al. Jianpi Qingchang Decoction Ameliorates Chronic Colitis in Piroxicam-Induced IL-10 Knockout Mice by Inhibiting Endoplasmic Reticulum Stress. Evid Based Complement Alternat Med. 2022;2022:7378807. Published 2022 Feb 9. doi:10.1155/2022/7378807. (上海中医药大学龙华医院) IF=无

10. Li C, Yu S, Li X, et al. Medicinal Formula Huazhi-Rougan Attenuates Non-Alcoholic Steatohepatitis Through Enhancing Fecal Bile Acid Excretion in Mice. Front Pharmacol. 2022;13:833414. Published 2022 Jun 1. doi:10.3389/fphar.2022.833414. (上海中医药大学附属龙华医院) IF=4.8

11. Zhou W, Zhu Z, Xiao X, et al. Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology. Biomed Pharmacother. 2021;143:112181. doi:10.1016/j.biopha.2021.112181. (上海中医药大学) IF=6.9